Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice
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چکیده
منابع مشابه
Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice.
One hypothesis for the etiology of behavioral disorders is that infection by a virus induces neuronal cell dysfunctions resulting in a wide range of behavioral abnormalities. However, a direct linkage between viral infections and neurobehavioral disturbances associated with human psychiatric disorders has not been identified. Here, we show that transgenic mice expressing the phosphoprotein (P) ...
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Neurobehavioral disorder is a serious consequence of a number of viral infections in the central nervous system (CNS). A line of evidence has demonstrated that viral infections are associated with disturbances in neural functions that may be caused by alteration of the brain homeostasis. Here, we examined the role of viral persistent infection in neuropsychiatric disorders by generating a trans...
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Borna disease virus is the prototype of a new family, Bornaviridae, within the order Mononegavirales, that is characterized by nuclear transcription, splicing, low level replication, and neurotropism. The products of five open reading frames predicted from the genomic sequence have been confirmed; however, expression of the sixth, corresponding to the putative viral polymerase (L), has not been...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1531155100